Impact of endogenous and exogenous progesterone exposure on stress biomarkers: a systematic review.
Climacteric
; 22(5): 435-441, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-31267780
ABSTRACT
Stress activates the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal axis (HPAA). Based on a systematic literature review of the impact of endogenous and exogenous exposure with natural progesterone on the stress response in healthy premenopausal and postmenopausal women, the following conclusions can be drawn the HPAA activity was not relevantly affected by endogenous progesterone exposure across the menstrual cycle, but might be reduced by exogenous micronized progesterone application; in contrast, the ANS has a sympathetic predominance in the (progesterone-dominated) luteal phase of the menstrual cycle. Future studies should assess various stress biomarkers under various hormonal conditions to, for example, allow for cardiovascular risk stratification in hormone users.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progesterona
/
Sistema Nervioso Autónomo
/
Estrés Fisiológico
Tipo de estudio:
Systematic_reviews
Límite:
Female
/
Humans
Idioma:
En
Revista:
Climacteric
Asunto de la revista:
GINECOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Suiza