Antibody persistence and booster response following MenACWY-CRM vaccination in children as assessed by two different assay methods.
Vaccine
; 37(32): 4460-4467, 2019 07 26.
Article
en En
| MEDLINE
| ID: mdl-31279564
ABSTRACT
BACKGROUND:
The quadrivalent meningococcal conjugate vaccine MenACWY-CRM has been shown to be immunogenic and well-tolerated in infants and toddlers. We evaluated antibody persistence for up to 4â¯years after vaccination with MenACWY-CRM in the first years of life and response to a booster dose administered at 60â¯months of age.METHODS:
This was phase 3b, open-label, multicenter extension trial (NCT01148017). We assessed by hSBA and rSBA the persistence of antibody responses to serogroups ACWY in 203 healthy 60-month-olds receiving 4 doses of MenACWY-CRM during infancy (ACWY-4 group), or 2 doses at 12/13 and 15â¯months or 1 dose at 18â¯months of age (ACWY-2 group). We administered a MenACWY-CRM dose to 224 primed and 45 naïve 60-month-olds and evaluated safety and antibody response 1â¯month later.RESULTS:
Antibody persistence measured by both assays was higher in primed than naïve 60-month-olds. The percentages of primed children with hSBA titers ≥8 was low for serogroup A (6-25%) and moderate for serogroups C (27-43%), Y (69-74%) and W (56-69%). For all serogroups, hSBA antibody geometric mean titers (GMTs) tended to be higher in the ACWY-2 than the ACWY-4 group. Post-booster/single dose, ≥96% of primed and ≥73% of naïve children had hSBA titers ≥8 against each serogroup, and hSBA GMTs were higher in primed children. The booster dose was well-tolerated and no safety concern was identified. We further assessed persistence using rSBA across different age groups and detected no overall correlation between rSBA and hSBA titers.CONCLUSIONS:
Primary vaccination of infants/toddlers with MenACWY-CRM resulted in moderate antibody persistence against serogroups C, W and Y for up to 4â¯years after the last priming dose. Regardless of priming schedule, a MenACWY-CRM booster dose at 60â¯months of age induced a robust immune response against all serogroups and was well-tolerated in all children.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
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2_ODS3
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3_ND
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4_TD
Problema de salud:
1_medicamentos_vacinas_tecnologias
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2_enfermedades_transmissibles
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3_zoonosis
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4_meningitis
Asunto principal:
Vacunas Meningococicas
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Anticuerpos Antibacterianos
Tipo de estudio:
Prognostic_studies
Límite:
Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Vaccine
Año:
2019
Tipo del documento:
Article