Artemisinin and its derivatives prevent Helicobacter pylori-induced gastric carcinogenesis via inhibition of NF-&#954;B signaling.

Su, Tao; Li, Fangyuan; Guan, Jiaji; Liu, Linxin; Huang, Ping; Wang, Ying; Qi, Xiaoxiao; Liu, Zhongqiu; Lu, Linlin; Wang, Dawei

Artemisinin and its derivatives prevent Helicobacter pylori-induced gastric carcinogenesis via inhibition of NF-κB signaling.

Su, Tao; Li, Fangyuan; Guan, Jiaji; Liu, Linxin; Huang, Ping; Wang, Ying; Qi, Xiaoxiao; Liu, Zhongqiu; Lu, Linlin; Wang, Dawei.

Afiliación

Su T; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Li F; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Guan J; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Liu L; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Huang P; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Wang Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Qi X; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Liu Z; Shunde Hospital of Guangzhou University of Chinese Medicine, Shunde, Guangdong, China; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou Universi
Lu L; Shunde Hospital of Guangzhou University of Chinese Medicine, Shunde, Guangdong, China; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou Universi
Wang D; Shunde Hospital of Guangzhou University of Chinese Medicine, Shunde, Guangdong, China. Electronic address: david@gzucm.edu.cn.

Phytomedicine ; 63: 152968, 2019 Oct.

Article en En | MEDLINE | ID: mdl-31280140

Asunto(s)

Anticarcinógenos/farmacología; Artemisininas/farmacología; Infecciones por Helicobacter/complicaciones; Helicobacter pylori/efectos de los fármacos; Neoplasias Gástricas/prevención & control; Animales; Artesunato/farmacología; Adhesión Bacteriana/efectos de los fármacos; Línea Celular Tumoral; Citocinas/metabolismo; Helicobacter pylori/patogenicidad; Humanos; Ratones Endogámicos C57BL; Pruebas de Sensibilidad Microbiana; FN-kappa B/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Neoplasias Gástricas/microbiología; Neoplasias Gástricas/patología

Palabras clave

ARTS, artesunate; Abbreviations: ART, artemisinin; Artemisinin; Artesunate; CFU, colony forming units; COX-2, cyclooxygenase-2; DHA, dehydroartemisinin; DMSO, dimethyl sulfoxide; Dihydroartemisinin; ELISA, enzyme-linked immunosorbent assay; Gastric cancer; Helicobacter pylori; IARC, International Agency for Research on Cancer; IL-8, interleukin-8; MNU, N-methyl-N-nitroso-urea; MOI, multiplicity of infection; NF-κB signaling; NF-κB, nuclear factor-κB; PBS, phosphate buffer solution; ROS, reactive oxygen species; TNF-α, tumor necrosis factor-α

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 4_TD / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 4_malaria / 6_digestive_diseases / 6_stomach_cancer Asunto principal: Neoplasias Gástricas / Helicobacter pylori / Infecciones por Helicobacter / Anticarcinógenos / Artemisininas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: China

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