New insights into resistance of Helicobacter pylori against third- and fourth-generation fluoroquinolones: A molecular docking study of prevalent GyrA mutations.

Salehi, Najmeh; Attaran, Bahareh; Eskini, Negin; Esmaeili, Maryam; Sharifirad, Atefeh; Sadeghi, Mehdi; Mohammadi, Marjan

Salehi, Najmeh; Attaran, Bahareh; Eskini, Negin; Esmaeili, Maryam; Sharifirad, Atefeh; Sadeghi, Mehdi; Mohammadi, Marjan.

Afiliación

Salehi N; Department of Bioinformatics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Attaran B; HPGC Research Group, Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran.
Eskini N; Department of Microbiology, Faculty of Biology, Alzahra University, Tehran, Iran.
Esmaeili M; HPGC Research Group, Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran.
Sharifirad A; HPGC Research Group, Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran.
Sadeghi M; HPGC Research Group, Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran.
Mohammadi M; National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.

Helicobacter ; 24(5): e12628, 2019 Oct.

Article en En | MEDLINE | ID: mdl-31282059

Asunto(s)

Antibacterianos/farmacología; Girasa de ADN/metabolismo; Farmacorresistencia Bacteriana; Gemifloxacina/farmacología; Helicobacter pylori/efectos de los fármacos; Levofloxacino/farmacología; Moxifloxacino/farmacología; Antibacterianos/metabolismo; Girasa de ADN/química; Girasa de ADN/genética; Gemifloxacina/metabolismo; Helicobacter pylori/enzimología; Humanos; Levofloxacino/metabolismo; Pruebas de Sensibilidad Microbiana; Simulación del Acoplamiento Molecular; Moxifloxacino/metabolismo; Proteínas Mutantes/química; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Mutación; Reacción en Cadena de la Polimerasa; Unión Proteica; Análisis de Secuencia de ADN

Palabras clave

Helicobacter pylori; GyrA; QRDR; docking; gemifloxacin; levofloxacin; moxifloxacin; resistance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Girasa de ADN / Farmacorresistencia Bacteriana / Levofloxacino / Moxifloxacino / Gemifloxacina / Antibacterianos Límite: Humans Idioma: En Revista: Helicobacter Asunto de la revista: BACTERIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Irán

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