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Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio in Outcome of Immune Checkpoint Inhibitors.
Xie, Xianhe; Liu, Junjin; Yang, Haitao; Chen, Huijuan; Zhou, Sijing; Lin, Heng; Liao, Ziyuan; Ding, Yin; Ling, Liting; Wang, Xuewen.
Afiliación
  • Xie X; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
  • Liu J; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
  • Yang H; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
  • Chen H; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
  • Zhou S; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
  • Lin H; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
  • Liao Z; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
  • Ding Y; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
  • Ling L; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
  • Wang X; a Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University , Fuzhou , China.
Cancer Invest ; 37(6): 265-274, 2019.
Article en En | MEDLINE | ID: mdl-31304800
ABSTRACT
A meta-analysis of 14 studies (16 cohorts) incorporating 1751 participants was performed to evaluate the correlation between baseline neutrophil-to-lymphocyte ratio (NLR) and outcome of immune checkpoint inhibitors (ICI). The pooled hazard ratio (HR) suggested elevated pretreatment NLR was associated with poor OS (HR 2.61, 95% confidence intervals (CI) 1.77-3.86, p < 0.00001) and PFS (HR 1.74, 95% CI 1.34-2.27, p < 0.0001). Stratified analyses on tumor types, ICI agents, the cutoff value of NLR and study regions exhibited the similar outcomes. This study demonstrated that elevated NLR was a predictor of poor OS and PFS for ICI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos / Neutrófilos / Antineoplásicos Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Cancer Invest Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos / Neutrófilos / Antineoplásicos Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Cancer Invest Año: 2019 Tipo del documento: Article País de afiliación: China