The antidepressant effects of apigenin are associated with the promotion of autophagy via the mTOR/AMPK/ULK1 pathway.
Mol Med Rep
; 20(3): 2867-2874, 2019 Sep.
Article
en En
| MEDLINE
| ID: mdl-31322238
ABSTRACT
The present study aimed to investigate whether apigenin elicits antidepressant effects in depressantlike mice via the regulation of autophagy. The depressantlike behaviors were established in a chronic restraint stress model. Male BALB/c mice were subjected to restraint stress for 6 h/day for a period of 21 days, and deficits in sucrose preference, tail suspension and forced swim tests were confirmed to be improved following oral apigenin. To investigate the underlining mechanisms, the hippocampal levels of p62 and microtubuleassociated protein light chain 3II/I (LC3II/I) were measured using western blot analysis. The expression levels of LC3II/I and p62 indicated that the significantly inhibited autophagy level induced by chronic restraint stress can be increased following apigenin treatment. Similar to the level of autophagy, the expression levels of adenosine monophosphateactivated protein kinase (AMPK) and Unc51 like autophagy activating kinase1 were downregulated after chronic restraint stress stimulation and, subsequently upregulated following treatment with apigenin. Conversely, the levels of mammalian target of rapamycin (mTOR) were increased in chronic restraint stress mice and inhibited by apigenin. Collectively, the present findings indicated that apigenin potentially promotes autophagy via the AMPK/mTOR pathway and induces antidepressive effects in chronic restraint stress mice.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autofagia
/
Transducción de Señal
/
Apigenina
/
Depresión
/
Antidepresivos
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Mol Med Rep
Año:
2019
Tipo del documento:
Article