Short-term ambient particle radioactivity level and renal function in older men: Insight from the Normative Aging Study.
Environ Int
; 131: 105018, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-31336254
ABSTRACT
BACKGROUND:
Whole-body and thoracic ionizing radiation exposure are both associated with the development of renal dysfunction. However, whether low-level environmental radiation from air pollution affects renal function remains unknown.OBJECTIVES:
We investigated the association of particle radioactivity (PR) with renal function defined by the estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) in the Normative Aging Study.METHODS:
This longitudinal analysis included 2491 medical visits from 809 white males enrolled between 1999 and 2013. The eGFR was calculated using the CKD-EPI and MDRD equations, and CKD cases were identified as those with an eGFR <60â¯mL/min/1.73â¯m2. Gross ß activity measured by five monitors of the U.S. Environmental Protection Agency's RadNet monitoring network was utilized to represent PR.RESULTS:
Ambient PR levels from 1 to 28â¯days prior to clinical visit demonstrated robust negative associations with both forms of eGFR, but not with the increased odds of CKD. An interquartile range higher 28-day average ambient PR level was significantly associated with 0.83-mL/min/1.73â¯m2 lower eGFR estimated by the CKD-EPI equation (95% confidence interval -1.46, -0.20, p-valueâ¯=â¯0.01). Controlling for PM2.5 or black carbon in the model slightly attenuated the PR effects on eGFR. However, in individuals with the highest levels (3rd tertile) of C-reactive protein (CRP) or fibrinogen, we observed robust associations of PR with eGFR and CKD, suggesting that systemic inflammation may modify the PR-eGFR and PR-CKD relationships.CONCLUSIONS:
Our study reveals adverse health effects of short-term low-level ambient PR on the renal function, providing evidence to guide further study of the interplay between PR, inflammation, and renal health.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_quimicos_contaminacion
Asunto principal:
Radiactividad
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Environ Int
Año:
2019
Tipo del documento:
Article