A New Method Based on Electron Diffraction for Detecting Nanoparticles in Injectable Medicines.
J Pharm Sci
; 109(1): 891-899, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31348938
ABSTRACT
A new method for detecting and characterizing nanoparticles in an injectable pharmaceutical solution is presented. The method is based on the simultaneous use, on those nanoparticles that are crystalline, of three-dimensional electron diffraction tomography and energy dispersive X-ray spectrometry. With three-dimensional electron diffraction tomography, the unit cell and the crystal symmetry of the nanoparticles are determined, while with energy dispersive X-ray spectrometry, the chemical composition is derived. With these data, through an inspection of a crystallographic database, it is possible to determine the crystal phase of the nanoparticles. The knowledge of the crystal phase is a valuable element for understanding the provenance and the formation of the nanoparticles, helping the researcher in solving any quality control issue related to the presence of nanoparticles in an injectable solution.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espectrometría por Rayos X
/
Preparaciones Farmacéuticas
/
Microscopía Electrónica de Transmisión
Idioma:
En
Revista:
J Pharm Sci
Año:
2020
Tipo del documento:
Article