Circulating Tumor Cells as a Tool for Assessing Tumor Heterogeneity.
Theranostics
; 9(16): 4580-4594, 2019.
Article
en En
| MEDLINE
| ID: mdl-31367241
ABSTRACT
Tumor heterogeneity is the major cause of failure in cancer prognosis and prediction. Accurately detecting heterogeneity for the development of biomarkers and the detection of the clones resistant to therapy is one of the main goals of contemporary medicine. Metastases belong to the natural history of cancer. The present review gives an overview on the origin of tumor heterogeneity. Recent progress has made it possible to isolate and characterize circulating tumor cells (CTCs), which are the drivers of the disease between the primary sites and metastatic foci. The most recent methods for characterizing CTCs are summarized and we discuss the power of CTC profiling for analyzing tumor heterogeneity in early and advanced diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
/
Medicina de Precisión
/
Células Neoplásicas Circulantes
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Theranostics
Año:
2019
Tipo del documento:
Article
País de afiliación:
Noruega