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Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice.
Del Fabbro, Lucian; de Gomes, Marcelo Gomes; Souza, Leandro Cattelan; Goes, André Rossito; Boeira, Silvana Peterini; Oliveira, Mauro Schneider; Furian, Ana Flávia; Jesse, Cristiano Ricardo.
Afiliación
  • Del Fabbro L; Universidade Federal do Pampa, Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (Laftambio Pampa), Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • de Gomes MG; Universidade Federal do Pampa, Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (Laftambio Pampa), Campus Itaqui, 97650-000 Itaqui, RS, Brazil; Universidade Federal do Pampa, Post Graduate Program in Pharmaceutical Sciences, Campus Uruguaiana, 97501-970 Urug
  • Souza LC; Universidade Federal do Pampa, Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (Laftambio Pampa), Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Goes AR; Universidade Federal do Pampa, Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (Laftambio Pampa), Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Boeira SP; Universidade Federal do Pampa, Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (Laftambio Pampa), Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Oliveira MS; Universidade Federal de Santa Maria, Laboratory of Neurotoxicity and Psychopharmacology (LABNEURO), Santa Maria, RS, Brazil.
  • Furian AF; Universidade Federal de Santa Maria, Laboratory of Pharmacology, Mycotoxins and Toxicology (LAFARMT), Santa Maria, RS, Brazil. Electronic address: ana.furian@ufsm.br.
  • Jesse CR; Universidade Federal do Pampa, Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (Laftambio Pampa), Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
J Neuroimmunol ; 335: 577007, 2019 10 15.
Article en En | MEDLINE | ID: mdl-31376787
ABSTRACT
We investigated the effects of chrysin in the experimental autoimmune encephomyelitis (EAE), a multiple sclerosis (MS) animal model. EAE was induced using myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide in C57BL/6 mice. Chrysin reduced weight loss, attenuated clinical signs and blunted the EAE-induced increase in histone deacetylase (HDCA) activity, glycogen synthase kinase-3ß (GSK-3ß) levels and pro-inflammatory cytokine levels as well as in the EAE-induced decrease in histone acetyltransferases 3 and 4 (HAT3, HAT4). Altogether, results demonstrate beneficial effects and potential targets of chrysin in EAE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Encefalomielitis Autoinmune Experimental / Antiinflamatorios Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2019 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Encefalomielitis Autoinmune Experimental / Antiinflamatorios Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2019 Tipo del documento: Article País de afiliación: Brasil
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