Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice.
J Neuroimmunol
; 335: 577007, 2019 10 15.
Article
en En
| MEDLINE
| ID: mdl-31376787
ABSTRACT
We investigated the effects of chrysin in the experimental autoimmune encephomyelitis (EAE), a multiple sclerosis (MS) animal model. EAE was induced using myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide in C57BL/6 mice. Chrysin reduced weight loss, attenuated clinical signs and blunted the EAE-induced increase in histone deacetylase (HDCA) activity, glycogen synthase kinase-3ß (GSK-3ß) levels and pro-inflammatory cytokine levels as well as in the EAE-induced decrease in histone acetyltransferases 3 and 4 (HAT3, HAT4). Altogether, results demonstrate beneficial effects and potential targets of chrysin in EAE.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Encefalomielitis Autoinmune Experimental
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil