Cobalt-Catalyzed &#945;-Arylation of Substituted &#945;-Halogeno ß-Lactams.

Koch, Vanessa; Lorion, Mélanie M; Barde, Etienne; Bräse, Stefan; Cossy, Janine

Cobalt-Catalyzed α-Arylation of Substituted α-Halogeno ß-Lactams.

Koch, Vanessa; Lorion, Mélanie M; Barde, Etienne; Bräse, Stefan; Cossy, Janine.

Afiliación

Koch V; Molecular, Macromolecular Chemistry and Materials (C3M) , ESPCI Paris , CNRS, PSL University, 10 rue Vauquelin , 75231 Paris Cedex 05, France.
Lorion MM; Institute for Organic Chemistry (IOC) , Karlsruhe Institute for Technology (KIT) , Fritz-Haber-Weg 6 , 76131 Karlsruhe , Germany.
Barde E; Molecular, Macromolecular Chemistry and Materials (C3M) , ESPCI Paris , CNRS, PSL University, 10 rue Vauquelin , 75231 Paris Cedex 05, France.
Bräse S; Molecular, Macromolecular Chemistry and Materials (C3M) , ESPCI Paris , CNRS, PSL University, 10 rue Vauquelin , 75231 Paris Cedex 05, France.
Cossy J; Institute for Organic Chemistry (IOC) , Karlsruhe Institute for Technology (KIT) , Fritz-Haber-Weg 6 , 76131 Karlsruhe , Germany.

Org Lett ; 21(16): 6241-6244, 2019 08 16.

Article en En | MEDLINE | ID: mdl-31390216

ABSTRACT

ABSTRACT

The treatment of 3-bromo ß-lactams by an aryl Grignard, in the presence of CoCl2 (2 mol %) and TMEDA (2 mol %) in THF, produces 3-aryl ß-lactams in good yields and excellent diastereoselectivity.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Francia

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