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Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
Saura, Cristina; Hlauschek, Dominik; Oliveira, Mafalda; Zardavas, Dimitrios; Jallitsch-Halper, Anita; de la Peña, Lorena; Nuciforo, Paolo; Ballestrero, Alberto; Dubsky, Peter; Lombard, Janine M; Vuylsteke, Peter; Castaneda, Carlos A; Colleoni, Marco; Santos Borges, Giuliano; Ciruelos, Eva; Fornier, Monica; Boer, Katalin; Bardia, Aditya; Wilson, Timothy R; Stout, Thomas J; Hsu, Jerry Y; Shi, Yi; Piccart, Martine; Gnant, Michael; Baselga, José; de Azambuja, Evandro.
Afiliación
  • Saura C; Vall d'Hebrón University Hospital, Vall d'Hebrón Institute of Oncology, Barcelona, Spain; SOLTI Breast Cancer Research Group, Barcelona, Spain. Electronic address: csaura@vhio.net.
  • Hlauschek D; Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria.
  • Oliveira M; Vall d'Hebrón University Hospital, Vall d'Hebrón Institute of Oncology, Barcelona, Spain; SOLTI Breast Cancer Research Group, Barcelona, Spain.
  • Zardavas D; Bristol-Myers Squibb Company, Lawrence, NJ, USA.
  • Jallitsch-Halper A; Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria.
  • de la Peña L; SOLTI Breast Cancer Research Group, Barcelona, Spain.
  • Nuciforo P; Vall d'Hebrón University Hospital, Vall d'Hebrón Institute of Oncology, Barcelona, Spain; SOLTI Breast Cancer Research Group, Barcelona, Spain.
  • Ballestrero A; University of Genoa - Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Policlinico San Martino, Genova; Gruppo Oncologico Italiano di Ricerca Clinica, Genova, Italy.
  • Dubsky P; Medical University of Vienna, Vienna, Austria; Hirslanden Klinik St Anna, Breast Centre, Lucerne, Switzerland.
  • Lombard JM; Breast Cancer Trials Australia New Zealand, University of Newcastle, Newcastle, NSW, Australia.
  • Vuylsteke P; European Organisation for Research and Treatment of Cancer, Breast Cancer Group, CHU Namur, Université Catholique de Louvain, Ottignies-Nouvain-la-Neuve, Belgium.
  • Castaneda CA; Grupo de Estudios Clinicos Oncologicos Peruano, Lima, Perú.
  • Colleoni M; Division of Medical Senology, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico and International Breast Cancer Study Group, Milan, Italy.
  • Santos Borges G; Centro de Novos Tratamentos Itajaí, Itajaí, Brazil.
  • Ciruelos E; SOLTI Breast Cancer Research Group, Barcelona, Spain; Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Fornier M; Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
  • Boer K; Szent Margit Hospital, Budapest, Hungary.
  • Bardia A; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Wilson TR; Genentech Inc, South San Francisco, CA, USA.
  • Stout TJ; Genentech Inc, South San Francisco, CA, USA.
  • Hsu JY; Genentech Inc, South San Francisco, CA, USA.
  • Shi Y; Genentech Inc, South San Francisco, CA, USA.
  • Piccart M; Breast International Group, Brussels, Belgium; Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  • Gnant M; Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; Medical University of Vienna, Vienna, Austria.
  • Baselga J; AstraZeneca, Gaithersburg, Maryland, USA.
  • de Azambuja E; Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Lancet Oncol ; 20(9): 1226-1238, 2019 09.
Article en En | MEDLINE | ID: mdl-31402321
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 1_doencas_nao_transmissiveis / 2_muertes_prematuras_enfermedades_notrasmisibles / 6_breast_cancer / 6_sense_organ_diseases Asunto principal: Oxazepinas / Neoplasias de la Mama / Fosfatidilinositol 3-Quinasa Clase I / Letrozol / Imidazoles Tipo de estudio: Clinical_trials Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 1_doencas_nao_transmissiveis / 2_muertes_prematuras_enfermedades_notrasmisibles / 6_breast_cancer / 6_sense_organ_diseases Asunto principal: Oxazepinas / Neoplasias de la Mama / Fosfatidilinositol 3-Quinasa Clase I / Letrozol / Imidazoles Tipo de estudio: Clinical_trials Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article