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Radiosynthesis of the diastereomerically pure (E)-[11 C]ABP688.
Bdair, Hussein; Tsai, I-Huang; Smart, Kelly; Benkelfat, Chawki; Leyton, Marco; Kostikov, Alexey.
Afiliación
  • Bdair H; McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada.
  • Tsai IH; McGill University, Department of Psychiatry, Montreal, Quebec, Canada.
  • Smart K; McGill University, McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada.
  • Benkelfat C; Yale University School of Medicine, Yale PET Center, New Haven, Connecticut.
  • Leyton M; McGill University, Department of Psychiatry, Montreal, Quebec, Canada.
  • Kostikov A; McGill University, Department of Psychiatry, Montreal, Quebec, Canada.
J Labelled Comp Radiopharm ; 62(12): 860-864, 2019 10.
Article en En | MEDLINE | ID: mdl-31418468
ABSTRACT
We report an efficient protocol for the radiosynthesis of diastereomerically pure (E)-[11 C]ABP688, a positron emission tomography (PET) tracer for metabotropic glutamate type 5 (mGlu5) receptor imaging. The protocol reliably provides sterile and pyrogen-free formulation of (E)-[11 C]ABP688 suitable for preclinical and clinical PET imaging with >99% diastereomeric excess (d.e.), >99% overall radiochemical purity (RCP), 14.9 ± 4.3% decay-corrected radiochemical yield (RCY), and 148.86 ± 79.8 GBq/µmol molar activity in 40 minutes from the end of bombardment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oximas / Piridinas / Radioisótopos de Carbono Tipo de estudio: Guideline Idioma: En Revista: J Labelled Comp Radiopharm Año: 2019 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oximas / Piridinas / Radioisótopos de Carbono Tipo de estudio: Guideline Idioma: En Revista: J Labelled Comp Radiopharm Año: 2019 Tipo del documento: Article País de afiliación: Canadá