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Haploidentical hematopoietic stem cell transplantation with αßTCR+/CD19+ depletion in pediatric patients with malignant and non-malignant disorders.
Bielorai, Bella; Jacoby, Elad; Varda-Bloom, Nira; Hutt, Daphna; Churi, Chaim; Vernitsky, Helly; Toren, Amos.
Afiliación
  • Bielorai B; Department of Pediatric Hematology-Oncology & BMT, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel. bella.bielorai@sheba.health.gov.il.
  • Jacoby E; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. bella.bielorai@sheba.health.gov.il.
  • Varda-Bloom N; Department of Pediatric Hematology-Oncology & BMT, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel.
  • Hutt D; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Churi C; Institute of Hematology, Sheba Medical Center, Ramat-Gan, Israel.
  • Vernitsky H; Department of Pediatric Hematology-Oncology & BMT, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel.
  • Toren A; Department of Pediatric Hematology-Oncology & BMT, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel.
Bone Marrow Transplant ; 54(Suppl 2): 694-697, 2019 08.
Article en En | MEDLINE | ID: mdl-31431715
ABSTRACT
Haploidntical hematopoietic stem cell transplantation has been increasingly used in recent years for patients without a matched donor. The αßTCR+/CD19+ depletion technique provide a graft that is enriched with CD34 cells, γδ-T-cells and natural killer. The current experience with αßTCR+/CD19+ depleted grafts in pediatric patients with malignant and non-malignant disorders, demonstrated rapid engraftment, improved immune reconstitution and low risk of GVHD. Future studies will need to define the optimal conditioning regimen in order to improve transplant outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depleción Linfocítica / Trasplante de Células Madre Hematopoyéticas / Antígenos CD19 / Acondicionamiento Pretrasplante / Trasplante Haploidéntico Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Israel
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depleción Linfocítica / Trasplante de Células Madre Hematopoyéticas / Antígenos CD19 / Acondicionamiento Pretrasplante / Trasplante Haploidéntico Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Israel