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GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency.
McDermott, Lee; Koes, David; Mohammed, Shabber; Iyer, Prema; Boby, Melissa; Balasubramanian, Venkatakrishnan; Geedy, Mackenzie; Katt, William; Cerione, Richard.
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  • McDermott L; University of Pittsburgh, Department of Pharmaceutical Sciences, Pittsburgh, PA 15260, USA; University of Pittsburgh, Drug Discovery Institute, Pittsburgh, PA 15269, USA. Electronic address: lam179@pitt.edu.
  • Koes D; University of Pittsburgh, Department of Computational and Systems Biology, Pittsburgh, PA 15260, USA.
  • Mohammed S; University of Pittsburgh, Department of Pharmaceutical Sciences, Pittsburgh, PA 15260, USA.
  • Iyer P; University of Pittsburgh, Department of Pharmaceutical Sciences, Pittsburgh, PA 15260, USA.
  • Boby M; University of Pittsburgh, Department of Pharmaceutical Sciences, Pittsburgh, PA 15260, USA.
  • Balasubramanian V; University of Pittsburgh, Department of Pharmaceutical Sciences, Pittsburgh, PA 15260, USA; SASTRA Deemed University, Department of Chemical Engineering, Tamil Nadu, Tirumalaisamudram, 613401, India.
  • Geedy M; University of Pittsburgh, Department of Pharmaceutical Sciences, Pittsburgh, PA 15260, USA.
  • Katt W; Cornell University, Department of Molecular Medicine, Ithaca, NY 14853, USA.
  • Cerione R; Cornell University, Department of Molecular Medicine, Ithaca, NY 14853, USA; Cornell University, Cornell High Energy Synchrotron Source (CHESS), Ithaca, NY 14853, USA; Cornell University, Department of Chemistry and Chemical Biology, Ithaca, NY 14853, USA.
Bioorg Med Chem Lett ; 29(19): 126632, 2019 10 01.
Article en En | MEDLINE | ID: mdl-31474484
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Neoplasias de la Mama / Inhibidores Enzimáticos / Bibliotecas de Moléculas Pequeñas / Glutaminasa / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Neoplasias de la Mama / Inhibidores Enzimáticos / Bibliotecas de Moléculas Pequeñas / Glutaminasa / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article