Preoperative Ultrasound Radiomics Signatures for Noninvasive Evaluation of Biological Characteristics of Intrahepatic Cholangiocarcinoma.
Acad Radiol
; 27(6): 785-797, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-31494003
ABSTRACT
RATIONALE AND OBJECTIVES:
The purpose of this study was to establish and validate radiomics signatures based on ultrasound (US) medicine images to assess the biological behaviors of intrahepatic cholangiocarcinoma (ICC) in a noninvasive manner. MATERIALS ANDMETHODS:
This study consisted of 128 ICC patients. We focused on evaluating six pathological features microvascular invasion, perineural invasion, differentiation, Ki-67, vascular endothelial growth factor, and cytokeratin 7. Region of interest (ROI) of ICC was identified by manually plotting the tumor contour on the grayscale US image. We extracted radiomics features from medical US imaging. Then, dimensionality reduction methods and classifiers were used to develop radiomic signatures for evaluating six pathological features in ICC. Finally, independent validation datasets were used to assess the radiomic signatures performance.RESULTS:
We extracted 1076 quantitative characteristic parameters on the US medicine images. Based on extracted radiomics features, the best performing radiomic signatures for evaluating microvascular invasion features were produced by hypothetical testâ¯+â¯support vector machine (SVM), perineural invasion subgroup were least absolute shrinkage and selection operatorâ¯+â¯principal component analysis + support vector machine, differentiation subgroup were hypothetical testâ¯+â¯decision tree, Ki-67 subgroup were hypothetical testâ¯+â¯logistic regression, vascular endothelial growth factor subgroup were hypothetical testâ¯+â¯Gradient Boosting Decision Tree (GBDT), and cytokeratin 7 subgroup were hypothetical testâ¯+â¯bagging, respectively.CONCLUSION:
Through the high-throughput radiomics analysis based on US medicine images, we proposed radiomics signatures that have moderate efficiency in predicting the biological behaviors of ICC noninvasively.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de los Conductos Biliares
/
Conductos Biliares Intrahepáticos
/
Colangiocarcinoma
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Acad Radiol
Asunto de la revista:
RADIOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
China