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Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells.
Kong, Xiangduo; Di, Linting; Fan, Yunshi; Zhou, Zhikuan; Feng, Xinjiang; Gai, Lizhi; Tian, Jiangwei; Lu, Hua.
Afiliación
  • Kong X; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, P. R. China. lizhigai@hznu.edu.cn hualu@hznu.edu.cn.
  • Di L; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, P. R. China. lizhigai@hznu.edu.cn hualu@hznu.edu.cn.
  • Fan Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, P. R. China. jwtian@cpu.edu.cn.
  • Zhou Z; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, P. R. China. lizhigai@hznu.edu.cn hualu@hznu.edu.cn.
  • Feng X; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, P. R. China. lizhigai@hznu.edu.cn hualu@hznu.edu.cn.
  • Gai L; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, P. R. China. lizhigai@hznu.edu.cn hualu@hznu.edu.cn.
  • Tian J; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, P. R. China. jwtian@cpu.edu.cn.
  • Lu H; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, P. R. China. lizhigai@hznu.edu.cn hualu@hznu.edu.cn.
Chem Commun (Camb) ; 55(77): 11567-11570, 2019 Sep 24.
Article en En | MEDLINE | ID: mdl-31495830
ABSTRACT
A small series of fluorescent lysosome-targeting probes based on the BODIPY fluorophore and containing morpholine and nitro groups were rationally designed. These probes emitted light from green to NIR wavelengths, and provided specificity for imaging the lysosomes of hypoxic cells. The electron-withdrawing nitrophenyl group at the meso position was found to lead to highly efficient nonradiative decay of the S1 state, and hence a recovery of fluorescence when reduction of the nitro group occurred under hypoxic conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Boro / Hipoxia de la Célula / Colorantes Fluorescentes / Lisosomas Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Boro / Hipoxia de la Célula / Colorantes Fluorescentes / Lisosomas Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article