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Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease.
Lee, Edmund C; Valencia, Tania; Allerson, Charles; Schairer, Annelie; Flaten, Andrea; Yheskel, Matanel; Kersjes, Kara; Li, Jian; Gatto, Sole; Takhar, Mandeep; Lockton, Steven; Pavlicek, Adam; Kim, Michael; Chu, Tiffany; Soriano, Randy; Davis, Scott; Androsavich, John R; Sarwary, Salma; Owen, Tate; Kaplan, Julia; Liu, Kai; Jang, Graham; Neben, Steven; Bentley, Philip; Wright, Timothy; Patel, Vishal.
Afiliación
  • Lee EC; Regulus Therapeutics Inc., San Diego, CA, 92121, USA. elee@regulusrx.com.
  • Valencia T; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Allerson C; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Schairer A; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Flaten A; Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Yheskel M; Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Kersjes K; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Li J; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Gatto S; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Takhar M; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Lockton S; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Pavlicek A; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Kim M; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Chu T; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Soriano R; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Davis S; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Androsavich JR; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Sarwary S; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Owen T; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Kaplan J; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Liu K; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Jang G; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Neben S; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Bentley P; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Wright T; Regulus Therapeutics Inc., San Diego, CA, 92121, USA.
  • Patel V; Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. vishald.patel@utsouthwestern.edu.
Nat Commun ; 10(1): 4148, 2019 09 12.
Article en En | MEDLINE | ID: mdl-31515477
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligonucleótidos / MicroARNs / Enfermedades Renales Poliquísticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligonucleótidos / MicroARNs / Enfermedades Renales Poliquísticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos