Lavage through percutaneous catheter drains in severe acute pancreatitis: Does it help?A randomized control trial.
Pancreatology
; 19(7): 929-934, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-31521496
ABSTRACT
AIMS:
There is no study comparing large volume lavage through image guided percutaneously placed drains in severe acute pancreatitis.METHODS:
Of the 114 randomized patients, 60 eligible candidates were randomly allocated to - Lavage Treatment (LT) group (28 patients) and Dependent Drainage (DD) group (32 patients). Primary end point was reversal of pre-existing organ failure, development of new onset organ failure, need for surgery, mortality and hospital stay.RESULTS:
Both the groups were comparable in terms of demographic data, onset and severity of pancreatitis. LT group had higher infected pancreatic necrosis (75% vs 50%,pâ¯=â¯0.047). On intention to treat analysis, lavage treatment group showed a significant reversal of persistent organ failure (84% vs 50%, pâ¯=â¯0.23), reduction in APACHEII scores (3.5⯱â¯3.405 vs 1.16⯱â¯3.811 pâ¯=â¯0.012), as measured at the time of placement of PCD to cessation of intervention. There was no difference in development of new onset organ failure in the two groups (25% vs37.5% p=.290). 75% in LT group and 69% in DD group improved with PCD alone. There was no difference in the catheter related complications and number of catheters used. The need for surgical intervention was comparable in two groups (18.8% vs 14.3% p=.737). There was a trend toward decreased mortality in group A (18.8% vs 28.8% p=.370).CONCLUSION:
Large volume lavage trough PCD improves organ failure and this translates into trend towards reduced mortality.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_digestive_diseases
Asunto principal:
Pancreatitis
/
Cateterismo
/
Irrigación Terapéutica
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pancreatology
Asunto de la revista:
ENDOCRINOLOGIA
/
GASTROENTEROLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
India