Improving Eflornithine Oral Bioavailability and Brain Uptake by Modulating Intercellular Junctions With an E-cadherin Peptide.

Yang, Sihyung; Chen, Yao; Feng, Mei; Rodriguez, Larry; Wu, Judy Qiju; Wang, Michael Zhuo

Yang, Sihyung; Chen, Yao; Feng, Mei; Rodriguez, Larry; Wu, Judy Qiju; Wang, Michael Zhuo.

Afiliación

Yang S; Department of Pharmaceutical Chemistry, School of Pharmacy, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047.
Chen Y; Department of Pharmaceutical Chemistry, School of Pharmacy, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047.
Feng M; Department of Pharmaceutical Chemistry, School of Pharmacy, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047.
Rodriguez L; Department of Chemistry, Kansas State University, 213 CBC Building, Manhattan, Kansas 66506.
Wu JQ; Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047.
Wang MZ; Department of Pharmaceutical Chemistry, School of Pharmacy, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047. Electronic address: michael.wang@ku.edu.

J Pharm Sci ; 108(12): 3870-3878, 2019 12.

Article en En | MEDLINE | ID: mdl-31545969

Asunto(s)

Encéfalo/metabolismo; Cadherinas/metabolismo; Eflornitina/metabolismo; Uniones Intercelulares/metabolismo; Péptidos/metabolismo; Administración Oral; Animales; Disponibilidad Biológica; Transporte Biológico/fisiología; Barrera Hematoencefálica/metabolismo; Células CACO-2; Línea Celular; Línea Celular Tumoral; Perros; Humanos; Células de Riñón Canino Madin Darby; Masculino; Permeabilidad; Ratas; Ratas Sprague-Dawley

Palabras clave

Caco-2 cells; absorption enhancer(s); blood-brain barrier (BBB); intercellular junctions; intestinal absorption; neglected disease(s); oral drug delivery; peptide(s)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_trypanosomiasis Asunto principal: Péptidos / Encéfalo / Cadherinas / Eflornitina / Uniones Intercelulares Límite: Animals / Humans / Male Idioma: En Revista: J Pharm Sci Año: 2019 Tipo del documento: Article

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