Ki67 index in intrinsic breast cancer subtypes and its association with prognostic parameters.
BMC Res Notes
; 12(1): 605, 2019 Sep 23.
Article
en En
| MEDLINE
| ID: mdl-31547858
ABSTRACT
OBJECTIVES:
Ki67 is the most commonly used marker to evaluate proliferative index in breast cancer, however no cutoff values have been clearly defined for high ki67 index. Cancer management should be according to loco-regional profile; therefore, we aimed to determine ki67 index in 1951 cases of intrinsic breast cancer subtypes and its association with other prognostic parameters in our set up.RESULTS:
Triple negative breast cancers showed highest ki67 index (mean 50.9 ± 23.7%) followed by Her2neu (mean 42.6 ± 21.6%) and luminal B cancers (mean 34.9 ± 20.05%). Metaplastic and medullary breast cancers significantly showed higher ki67 index as compared to ductal carcinoma, NOS. No significant association of ki67 index was noted with any of the histologic parameters in different subtypes of breast cancer expect for tumor grade. Although, ki67 index is a valuable biomarker in breast cancer, however no independent prognostic significance of ki67 could be established in our study.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Adenocarcinoma
/
Biomarcadores de Tumor
/
Carcinoma Medular
/
Carcinoma Ductal de Mama
/
Adenocarcinoma Mucinoso
/
Antígeno Ki-67
/
Neoplasias de la Mama Triple Negativas
/
Carcinoma de Mama in situ
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
BMC Res Notes
Año:
2019
Tipo del documento:
Article
País de afiliación:
Pakistán