Your browser doesn't support javascript.
loading
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas.
Guerreiro Stucklin, Ana S; Ryall, Scott; Fukuoka, Kohei; Zapotocky, Michal; Lassaletta, Alvaro; Li, Christopher; Bridge, Taylor; Kim, Byungjin; Arnoldo, Anthony; Kowalski, Paul E; Zhong, Yvonne; Johnson, Monique; Li, Claire; Ramani, Arun K; Siddaway, Robert; Nobre, Liana Figueiredo; de Antonellis, Pasqualino; Dunham, Christopher; Cheng, Sylvia; Boué, Daniel R; Finlay, Jonathan L; Coven, Scott L; de Prada, Inmaculada; Perez-Somarriba, Marta; Faria, Claudia C; Grotzer, Michael A; Rushing, Elisabeth; Sumerauer, David; Zamecnik, Josef; Krskova, Lenka; Garcia Ariza, Miguel; Cruz, Ofelia; Morales La Madrid, Andres; Solano, Palma; Terashima, Keita; Nakano, Yoshiko; Ichimura, Koichi; Nagane, Motoo; Sakamoto, Hiroaki; Gil-da-Costa, Maria Joao; Silva, Roberto; Johnston, Donna L; Michaud, Jean; Wilson, Bev; van Landeghem, Frank K H; Oviedo, Angelica; McNeely, P Daniel; Crooks, Bruce; Fried, Iris; Zhukova, Nataliya.
Afiliación
  • Guerreiro Stucklin AS; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
  • Ryall S; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Fukuoka K; Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Zapotocky M; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
  • Lassaletta A; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
  • Li C; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Bridge T; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  • Kim B; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Arnoldo A; Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Kowalski PE; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Zhong Y; Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Johnson M; Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
  • Li C; Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Ramani AK; Department of Pediatric Hematology and Oncology, Hospital Universitario Niño Jesús, Madrid, Spain.
  • Siddaway R; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
  • Nobre LF; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • de Antonellis P; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  • Dunham C; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
  • Cheng S; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Boué DR; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
  • Finlay JL; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Coven SL; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  • de Prada I; Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
  • Perez-Somarriba M; Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
  • Faria CC; Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
  • Grotzer MA; Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
  • Rushing E; Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
  • Sumerauer D; Centre for Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
  • Zamecnik J; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
  • Krskova L; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Garcia Ariza M; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Cruz O; Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Morales La Madrid A; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
  • Solano P; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
  • Terashima K; Division of Anatomic Pathology, British Columbia Children's Hospital, Vancouver, BC, Canada.
  • Nakano Y; Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada.
  • Ichimura K; Department of Pediatrics, The University of British Columbia, Vancouver, BC, Canada.
  • Nagane M; Division of Hematology/Oncology/BMT, British Columbia Children's Hospital, Vancouver, BC, Canada.
  • Sakamoto H; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
  • Gil-da-Costa MJ; Department of Pathology, The Ohio State University College of Medicine, Columbus, OH, USA.
  • Silva R; Division of Hematology/Oncology/Bone Marrow Transplantation, Nationwide Children's Hospital, Columbus, OH, USA.
  • Johnston DL; Division of Hematology/Oncology/Bone Marrow Transplantation, Nationwide Children's Hospital, Columbus, OH, USA.
  • Michaud J; Department of Pathology, Hospital Universitario Niño Jesús, Madrid, Spain.
  • Wilson B; Department of Pediatric Hematology and Oncology, Hospital Universitario Niño Jesús, Madrid, Spain.
  • van Landeghem FKH; Division of Neurosurgery, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal.
  • Oviedo A; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
  • McNeely PD; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
  • Crooks B; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland.
  • Fried I; Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
  • Zhukova N; Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Nat Commun ; 10(1): 4343, 2019 09 25.
Article en En | MEDLINE | ID: mdl-31554817
ABSTRACT
Infant gliomas have paradoxical clinical behavior compared to those in children and adults low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of clinically annotated infant gliomas, revealing 3 clinical subgroups. Group 1 tumors arise in the cerebral hemispheres and harbor alterations in the receptor tyrosine kinases ALK, ROS1, NTRK and MET. These are typically single-events and confer an intermediate outcome. Groups 2 and 3 gliomas harbor RAS/MAPK pathway mutations and arise in the hemispheres and midline, respectively. Group 2 tumors have excellent long-term survival, while group 3 tumors progress rapidly and do not respond well to chemoradiation. We conclude that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Regulación Neoplásica de la Expresión Génica / Proteínas Tirosina Quinasas Receptoras / Metilación de ADN / Epigenómica / Glioma Límite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Regulación Neoplásica de la Expresión Génica / Proteínas Tirosina Quinasas Receptoras / Metilación de ADN / Epigenómica / Glioma Límite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá