Resurgent and Gating Pore Currents Induced by <i>De Novo SCN2A</i> Epilepsy Mutations.

Mason, Emily R; Wu, Fenfen; Patel, Reesha R; Xiao, Yucheng; Cannon, Stephen C; Cummins, Theodore R

Resurgent and Gating Pore Currents Induced by De Novo SCN2A Epilepsy Mutations.

Mason, Emily R; Wu, Fenfen; Patel, Reesha R; Xiao, Yucheng; Cannon, Stephen C; Cummins, Theodore R.

Afiliación

Mason ER; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202 emmason@iu.edu.
Wu F; Department of Physiology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095-1751.
Patel RR; Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN 46202.
Xiao Y; School of Science, Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202.
Cannon SC; Department of Physiology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095-1751.
Cummins TR; School of Science, Biology Department Chair, Indiana University-Purdue University of Indianapolis, Indianapolis, IN 46202.

eNeuro ; 6(5)2019.

Article en En | MEDLINE | ID: mdl-31558572

Asunto(s)

Epilepsia/genética; Activación del Canal Iónico/genética; Canal de Sodio Activado por Voltaje NAV1.2/genética; Potenciales de Acción/genética; Animales; Células HEK293; Humanos; Mutación Puntual/genética; Xenopus laevis

Palabras clave

Nav1.2; channelopathies; epilepsy; gating pore current; resurgent current; whole-cell electrophysiology

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activación del Canal Iónico / Epilepsia / Canal de Sodio Activado por Voltaje NAV1.2 Límite: Animals / Humans Idioma: En Revista: ENeuro Año: 2019 Tipo del documento: Article

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