Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomized double blinded clinical trial.
J Ethnopharmacol
; 247: 112226, 2020 Jan 30.
Article
en En
| MEDLINE
| ID: mdl-31574343
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Licorice preparations are used as neuroprotective remedies in Persian ethnomedicine, in order to prevent from disabilities in neurodegenerative conditions like Parkinson's disease (PD). AIM OF THE STUDY This study was designed to determine the licorice (root of Glycyrrhiza glabra L.) effectiveness as an adjunct treatment in the PD management. MATERIAL AND METHODS:
In this double-blinded trial, 128 patients were assessed for eligibility criteria. Seventy-eight patients were ineligible and 11 of them refused from participating. Thirty-nine PD patients (YAHR stagingâ¯≤â¯3) were divided into two groups by random. The patients received oral licorice or placebo syrups with a dose of 5â¯cc, twice a day for 6 months. High-performance liquid chromatography and spectrophotometric instruments determined licorice syrup constituents. The patients' situation for Unified Parkinson's rating scale (UPDRS) was assessed every 6 weeks for the duration of six months. In addition, patients' blood pressure, blood glucose, sodium and potassium levels, quality of life and dizziness were determined.RESULTS:
Six weeks after intervention, total UPDRS, daily activities and tremor were significantly improved with a considerable effect size. A significant better motor test and rigidity scores were observed 4 months after licorice intake (pâ¯>â¯0.05). No electrolyte abnormality, significant changes in blood pressure or blood glucose levels were observed during the study. Each 5cc of syrup contained 136â¯mg of licorice extract with 12.14â¯mg glycyrrhizic acid, and also 136⯵g of polyphenols.CONCLUSION:
The licorice intake could improve the symptoms in PD patients without serious adverse events.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
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Extractos Vegetales
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Glycyrrhiza
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Antiparkinsonianos
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
Aspecto:
Patient_preference
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Ethnopharmacol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Irán