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The MicroRNA Centrism in the Orchestration of Neuroinflammation in Neurodegenerative Diseases.
Nuzziello, Nicoletta; Liguori, Maria.
Afiliación
  • Nuzziello N; National Research Council, Institute of Biomedical Technologies, Bari Unit, 70126 Bari, Italy. nicoletta.nuzziello@ba.itb.cnr.it.
  • Liguori M; National Research Council, Institute of Biomedical Technologies, Bari Unit, 70126 Bari, Italy. maria.liguori@cnr.it.
Cells ; 8(10)2019 10 02.
Article en En | MEDLINE | ID: mdl-31581723
ABSTRACT
MicroRNAs (miRNAs) are small non-coding RNAs with a unique ability to regulate the transcriptomic profile by binding to complementary regulatory RNA sequences. The ability of miRNAs to enhance (proinflammatory miRNAs) or restrict (anti-inflammatory miRNAs) inflammatory signalling within the central nervous system is an area of ongoing research, particularly in the context of disorders that feature neuroinflammation, including neurodegenerative diseases (NDDs). Furthermore, the discovery of competing endogenous RNAs (ceRNAs) has led to an increase in the complexity of miRNA-mediated gene regulation, with a paradigm shift from a unidirectional to a bidirectional regulation, where miRNA acts as both a regulator and is regulated by ceRNAs. Increasing evidence has revealed that ceRNAs, including long non-coding RNAs, circular RNAs, and pseudogenes, can act as miRNA sponges to regulate neuroinflammation in NDDs within complex cross-talk regulatory machinery, which is referred to as ceRNA network (ceRNET). In this review, we discuss the role of miRNAs in neuroinflammatory regulation and the manner in which cellular and vesicular ceRNETs could influence neuroinflammatory dynamics in complex multifactorial diseases, such as NDDs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Enfermedades Neurodegenerativas / MicroARNs / Redes Reguladoras de Genes / Inflamación Límite: Animals / Humans Idioma: En Revista: Cells Año: 2019 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Enfermedades Neurodegenerativas / MicroARNs / Redes Reguladoras de Genes / Inflamación Límite: Animals / Humans Idioma: En Revista: Cells Año: 2019 Tipo del documento: Article País de afiliación: Italia
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