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Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication.
Kamata, Mai; Takeuchi, Toshifumi; Hayashi, Ei; Nishioka, Kazane; Oshima, Mizuki; Iwamoto, Masashi; Nishiuchi, Kota; Kamo, Shogo; Tomoshige, Shusuke; Watashi, Koichi; Kamisuki, Shinji; Ohrui, Hiroshi; Sugawara, Fumio; Kuramochi, Kouji.
Afiliación
  • Kamata M; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Takeuchi T; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Hayashi E; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Nishioka K; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Oshima M; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
  • Iwamoto M; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Nishiuchi K; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
  • Kamo S; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Tomoshige S; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
  • Watashi K; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Kamisuki S; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Ohrui H; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Sugawara F; Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan.
  • Kuramochi K; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Biosci Biotechnol Biochem ; 84(2): 217-227, 2020 Feb.
Article en En | MEDLINE | ID: mdl-31589093
ABSTRACT
4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) and 4'-ethynyl-2'-deoxyadenosine (EdA) are nucleoside analogues which inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. EdAP, a cyclosaligenyl (cycloSal) phosphate derivative of EdA, inhibits the replication of the influenza A virus. The common structural feature of these compounds is the ethynyl group at the 4'-position. In this study, these nucleoside analogues were prepared by a common synthetic strategy starting from the known 1,2-di-O-acetyl-D-ribofuranose. Biological evaluation of EdAP revealed that this compound reduced hepatitis B virus (HBV) replication dose-dependently without cytotoxicity against host cells tested in this study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: Antivirales / Replicación Viral / Virus de la Hepatitis B / Desoxiadenosinas / Nucleótidos de Desoxiadenina Límite: Humans Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: Antivirales / Replicación Viral / Virus de la Hepatitis B / Desoxiadenosinas / Nucleótidos de Desoxiadenina Límite: Humans Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón