Commercial Quinolone Ear Drops Cause Perforations in Intact Rat Tympanic Membranes.
Otol Neurotol
; 40(10): 1386-1391, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31592822
ABSTRACT
HYPOTHESIS:
Commercial quinolone ear drops may promote the development of perforations (TMPs) in intact tympanic membrane (TMs).BACKGROUND:
Quinolone ear drops have been associated with TMPs after myringotomy +/- tube placement in a drug-specific manner and potentiation by steroids.METHODS:
Rats were randomized to six groups (10/group), with one ear receiving otic instillation of dexamethasone, ofloxacin, ciprofloxacin, ofloxacin + dexamethasone, ciprofloxacin + dexamethasone, or neomycin + polymyxin + hydrocortisone-all commercial formulations and at standard clinical concentrations-and the contralateral ear receiving saline, twice daily for 10 days. TMs were assessed over 42 days.RESULTS:
No TMPs were seen in ears treated with saline, dexamethasone, or neomycin. At day 10, TMPs were seen in one of 10 ofloxacin- and three of 10 ciprofloxacin + dexamethasone-treated ears (pâ=â0.038). At day 14, the ofloxacin TMP healed. In contrast, the three ciprofloxacin + dexamethasone TMPs remained and one new TMP developed in this group. A ciprofloxacin and an ofloxacin + dexamethasone-treated ears also had TMPs (pâ=â0.023). By day 21, the ofloxacin + dexamethasone TMP and two of four of the ciprofloxacin + dexamethasone TMPs healed but two new TMPs were seen in ciprofloxacin + dexamethasone ears (pâ=â0.0006). At day 28, 1 of 10 ciprofloxacin and 4 of 10 ciprofloxacin + dexamethasone-treated ears had TMPs (pâ=â0.0006). By day 35, only one ciprofloxacin + dexamethasone had TMP (pâ=â0.42). All TMPS were healed at day 42.CONCLUSIONS:
Application of commercial quinolone ear drops can cause TMPs in intact TMs. This effect appears to be drug-specific and potentiated by steroids.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Membrana Timpánica
/
Dexametasona
/
Neomicina
/
Ofloxacino
/
Ciprofloxacina
/
Perforación de la Membrana Timpánica
/
Quinolonas
Límite:
Animals
Idioma:
En
Revista:
Otol Neurotol
Asunto de la revista:
NEUROLOGIA
/
OTORRINOLARINGOLOGIA
Año:
2019
Tipo del documento:
Article