Hepatitis B virus-triggered PTEN/ß-catenin/c-Myc signaling enhances PD-L1 expression to promote immune evasion.

Sun, Yishuang; Yu, Mengxue; Qu, Mengmeng; Ma, Yuhong; Zheng, Dandan; Yue, Yanan; Guo, Shuting; Tang, Li; Li, Guorui; Zheng, Weishuai; Wang, Min; Guo, Deyin; Li, Changyong

Sun, Yishuang; Yu, Mengxue; Qu, Mengmeng; Ma, Yuhong; Zheng, Dandan; Yue, Yanan; Guo, Shuting; Tang, Li; Li, Guorui; Zheng, Weishuai; Wang, Min; Guo, Deyin; Li, Changyong.

Afiliación

Sun Y; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Yu M; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Qu M; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Ma Y; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Zheng D; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Yue Y; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Guo S; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Tang L; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Li G; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Zheng W; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Wang M; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Guo D; Laboratory of Medical Virology, School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
Li C; School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.

Am J Physiol Gastrointest Liver Physiol ; 318(1): G162-G173, 2020 01 01.

Article en En | MEDLINE | ID: mdl-31604033

Asunto(s)

Antígeno B7-H1/metabolismo; Virus de la Hepatitis B/metabolismo; Hepatitis B Crónica/metabolismo; Hepatocitos/enzimología; Evasión Inmune; Fosfohidrolasa PTEN/metabolismo; Proteínas Proto-Oncogénicas c-myc/metabolismo; Linfocitos T/enzimología; beta Catenina/metabolismo; Animales; Técnicas de Cocultivo; Modelos Animales de Enfermedad; Productos del Gen pol/genética; Productos del Gen pol/metabolismo; Células Hep G2; Virus de la Hepatitis B/genética; Virus de la Hepatitis B/inmunología; Hepatitis B Crónica/inmunología; Hepatitis B Crónica/virología; Hepatocitos/inmunología; Hepatocitos/virología; Humanos; Células Jurkat; Activación de Linfocitos; Masculino; Ratones Endogámicos BALB C; Transducción de Señal; Linfocitos T/inmunología; Linfocitos T/virología; Transactivadores/genética; Transactivadores/metabolismo; Proteínas Reguladoras y Accesorias Virales

Palabras clave

HBV; PD-L1; PTEN; immune evasion; ß-catenin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 4_TD / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 2_enfermedades_transmissibles / 4_hepatitis / 6_digestive_diseases Asunto principal: Linfocitos T / Virus de la Hepatitis B / Proteínas Proto-Oncogénicas c-myc / Hepatitis B Crónica / Hepatocitos / Fosfohidrolasa PTEN / Beta Catenina / Evasión Inmune / Antígeno B7-H1 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Am J Physiol Gastrointest Liver Physiol Asunto de la revista: FISIOLOGIA / GASTROENTEROLOGIA Año: 2020 Tipo del documento: Article

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