SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress.
Steroids
; 153: 108520, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31604074
ABSTRACT
In order to adequately respond to stressful stimuli, glucocorticoids (GCs) target almost every tissue of the body. By exerting a negative feedback loop in the hypothalamic-pituitary-adrenal (HPA) axis GCs inhibit their own synthesis and restore homeostasis. GCs actions are mostly mediated by the GC receptor (GR), a member of the nuclear receptor superfamily. Alterations of the GR activity have been associatedto different diseases including mood disorders and can lead to severe complication. Therefore, understanding the molecular complexity of GR modulation is mandatory for the development of new and effective drugs for treating GR-associated disorders. FKBP51 is a GR chaperone that has gained much attention because it is a strong inhibitor of GR activity and has a crucial role in psychiatric diseases. Both GR and FKBP51 activity are regulated by SUMOylation, a posttranslational (PTM). In this review, we focus on the impact of SUMO-conjugation as a regulator of this pathway.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
/
Receptores de Glucocorticoides
/
Proteínas de Unión a Tacrolimus
/
Enzimas Activadoras de Ubiquitina
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Steroids
Año:
2020
Tipo del documento:
Article