Mass balance and metabolite profiling of <sup>14</sup>C-guadecitabine in patients with advanced cancer.

Roosendaal, Jeroen; Rosing, Hilde; Lucas, Luc; Gebretensae, Abadi; Huitema, Alwin D R; van Dongen, Marloes G; Beijnen, Jos H; Oganesian, Aram

Mass balance and metabolite profiling of ¹⁴C-guadecitabine in patients with advanced cancer.

Roosendaal, Jeroen; Rosing, Hilde; Lucas, Luc; Gebretensae, Abadi; Huitema, Alwin D R; van Dongen, Marloes G; Beijnen, Jos H; Oganesian, Aram.

Afiliación

Roosendaal J; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands. j.roosendaal@nki.nl.
Rosing H; Division of Pharmacoepidemiology and Clinical Pharmacology, Science Faculty, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. j.roosendaal@nki.nl.
Lucas L; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Gebretensae A; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Huitema ADR; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
van Dongen MG; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Beijnen JH; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Oganesian A; Division of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

Invest New Drugs ; 38(4): 1085-1095, 2020 08.

Article en En | MEDLINE | ID: mdl-31605293

Asunto(s)

Antineoplásicos/farmacocinética; Azacitidina/análogos & derivados; Neoplasias/metabolismo; Anciano; Antineoplásicos/sangre; Antineoplásicos/orina; Azacitidina/sangre; Azacitidina/farmacocinética; Azacitidina/orina; Radioisótopos de Carbono; Femenino; Humanos; Masculino; Persona de Mediana Edad; Neoplasias/sangre; Neoplasias/orina

Palabras clave

14C-radiolabeled; Guadecitabine; Mass balance; Metabolite; Pharmacokinetics; ß-decitabine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azacitidina / Neoplasias / Antineoplásicos Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos

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