Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission.
Rev Soc Bras Med Trop
; 52: e20190252, 2019.
Article
en En
| MEDLINE
| ID: mdl-31618284
ABSTRACT
INTRODUCTION:
In Brazil, Biomphalaria glabrata, B. tenagophila, and B. straminea are intermediate hosts of Schistosoma mansoni, the etiological agent of schistosomiasis mansoni. Molluscicide use is recommended by the WHO for controlling the transmission of this parasite. Euphorbia milii latex has shown promising results as an alternative molluscicide. Thus, a natural molluscicide prototype kit based on freeze-dried E. milii latex was developed and evaluated against Biomphalaria spp.METHODS:
E. milii latex was collected, processed, and lyophilized. Two diluents were defined for freeze-dried latex rehydration, and a prototype kit, called MoluSchall, was produced. A stability test was conducted using prototype kits stored at different temperatures, and a toxicity assay was performed using Danio rerio. Additionally, MoluSchall was tested against B. glabrata under semi-natural conditions according to defined conditions in the laboratory.RESULTS:
MoluSchall was lethal to three Brazilian snail species while exhibiting low toxicity to D. rerio. Regardless of storage temperature, MoluSchall was stable for 24 months and was effective against B. glabrata under semi-natural conditions, with the same LD100 as observed under laboratory conditions.CONCLUSIONS:
MoluSchall is a natural, effective, and inexpensive molluscicide with lower environmental toxicity than existing molluscicides. Its production offers a possible alternative strategy for controlling S. mansoni transmission.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
/
3_ND
Problema de salud:
1_doencas_transmissiveis
/
2_enfermedades_transmissibles
/
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Schistosoma mansoni
/
Biomphalaria
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Esquistosomiasis mansoni
/
Euphorbia
/
Látex
/
Moluscocidas
Límite:
Animals
Idioma:
En
Revista:
Rev Soc Bras Med Trop
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil