Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish.
Cell Rep
; 29(4): 1041-1054.e5, 2019 10 22.
Article
en En
| MEDLINE
| ID: mdl-31644901
ABSTRACT
During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10+ cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regeneración
/
Proteínas de Pez Cebra
/
Miocitos Cardíacos
/
Factores de Transcripción SOXE
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Cell Rep
Año:
2019
Tipo del documento:
Article
País de afiliación:
Suiza