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An integration-free iPSC line (SDQLCHi012-A) derived from a patient with inflammatory bowel disease- 28 carrying compound heterozygote mutations in IL10RA gene.
Ma, Yanyan; Zhang, Haiyan; Zhang, Shisong; Dong, Rui; Yang, Xiaomeng; Li, Yue; Guan, Jingyun; Gai, Zhongtao; Liu, Yi.
Afiliación
  • Ma Y; Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
  • Zhang H; Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
  • Zhang S; General Surgical Department, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
  • Dong R; Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
  • Yang X; Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
  • Li Y; Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
  • Guan J; Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
  • Gai Z; Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
  • Liu Y; Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China. Electronic address: y_liu99@sina.com.
Stem Cell Res ; 41: 101577, 2019 12.
Article en En | MEDLINE | ID: mdl-31648101
ABSTRACT
Induced pluripotent stem cell (iPSC) line (SDQLCHi012-A) was generated from peripheral blood mononuclear cells of an 11-month-old male who was diagnosed as inflammatory bowel disease-28 caused by compound heterozygote for IL10RA mutations (c.188 + 1G > A and c.301C > T). Non-integrating episomal vectors coding OCT4, SOX2, KLF4, BCL-XL and MYC were used for reprogramming. The established iPSC line contained the same mutations identified in the patient, showed a normal karyotype, differentiation potential in vitro and expressed pluripotency markers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Subunidad alfa del Receptor de Interleucina-10 / Heterocigoto / Mutación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Stem Cell Res Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Subunidad alfa del Receptor de Interleucina-10 / Heterocigoto / Mutación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Stem Cell Res Año: 2019 Tipo del documento: Article País de afiliación: China