End of season influenza vaccine effectiveness in primary care in adults and children in the United Kingdom in 2018/19.
Vaccine
; 38(3): 489-497, 2020 01 16.
Article
en En
| MEDLINE
| ID: mdl-31685296
ABSTRACT
2018/19 was the first season of introduction of a newly licensed adjuvanted influenza vaccine (aTIV) for adults aged 65â¯years and over and the sixth season in the roll-out of a childhood influenza vaccination programme with a quadrivalent live attenuated influenza vaccine (LAIV). The season saw mainly A(H1N1)pdm09 and latterly A(H3N2) circulation. End-of-season adjusted vaccine effectiveness (aVE) estimates against laboratory confirmed influenza infection in primary care were calculated using the test negative case control method adjusting for key confounders. End-of-season aVE was 44.3% (95% CI 26.8, 57.7) against all laboratory-confirmed influenza; 45.7% (95% CI 26.0, 60.1) against influenza A(H1N1)pdm09 and 35.1% (95% CI -3.7,59.3) against A(H3N2). Overall aVE was 49.9% (95%CI -13.7, 77.9) for all thoseâ¯≥â¯65â¯years of age and 62.0% (95% CI 3.4, 85.0) for those who received aTIV. Overall aVE for 2-17â¯year olds receiving LAIV was 48.6% (95% CI -4.4, 74.7). The paper provides evidence of overall significant influenza VE in 2018/19, most notably against influenza A(H1N1)pdm09, however, as seen in 2017/18, there was reduced, non-significant VE against A(H3N2). aTIV provided significant protection for those 65â¯years of age and over.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
Problema de salud:
1_doencas_transmissiveis
/
1_medicamentos_vacinas_tecnologias
/
2_enfermedades_transmissibles
Asunto principal:
Atención Primaria de Salud
/
Estaciones del Año
/
Vacunas contra la Influenza
/
Gripe Humana
/
Subtipo H1N1 del Virus de la Influenza A
/
Subtipo H3N2 del Virus de la Influenza A
Límite:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Vaccine
Año:
2020
Tipo del documento:
Article