Plasma trimethylamine N-oxide, a gut microbe-generated phosphatidylcholine metabolite, is associated with autism spectrum disorders.
Neurotoxicology
; 76: 93-98, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31704102
ABSTRACT
OBJECTIVE:
The compositions of the gut microbiota and its metabolites were altered in individuals with Autism Spectrum Disorder (ASD). The aim of this study was to assess whether plasma levels of gut-derived metabolite trimethylamine N-oxide (TMAO) were associated with ASD and the degree of symptom severity.METHODS:
From September 2017 to January 2019, a total of three hundred and twenty-eight Chinese children (164 with ASD and 164 their age-sex matched control subjects) aged 3-8 years were included. TMAO levels in plasma were determined using high-performance liquid chromatography tandem mass spectrometry (LC/MS/MS). Logistic regression analysis was used to examine the TMAO-ASD association.RESULTS:
In the study, the median age of the ASD group was 5 years (interquartile range [IQR], 4-6 years) and 129 (78.7%) were boys. The median plasma levels of TMAO in children with ASD and typically-developing (TD) children at admission were 4.2 (IQR, 3.0-5.6) µmol/l and 3.0 (2.0-4.4) µmol/l, respectively (Pâ¯<â¯0.001). For each 1⯵mol/l increase of plasma TMAO, the unadjusted and adjusted risk of ASD would be increased by 54% (with the odds ratios [OR] of 1.54; 95% confidence intervals [CI] 1.32-1.78; Pâ¯<â¯0.001) and 27% (1.27 [1.10-1.45], Pâ¯<â¯0.001), respectively. Symptom severity was classified as mild-to-moderate (CARSâ¯<â¯37) for 66 children with ASD (40.2%). In these children, the plasma levels of TMAO were lower than in the 98 children with ASD (59.8%) whose symptoms were classified as severe (CARSâ¯>â¯36) (3.5[2.5-4.9] µmol/l vs. 4.5(3.7-6.0) µmol/l; Pâ¯<â¯0.001). For each 1⯵mol/l increase of plasma TMAO, the unadjusted and adjusted risk of severe autism would be increased by 61% (with the OR of 1.61 [95% CI 1.28-2.01], Pâ¯<â¯0.001) and 31% (1.31 [1.08-1.49], Pâ¯<â¯0.001), respectively.CONCLUSIONS:
Elevated plasma levels of TMAO were associated with ASD and symptom severity.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Fosfatidilcolinas
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Trastorno del Espectro Autista
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Microbioma Gastrointestinal
/
Metilaminas
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Neurotoxicology
Año:
2020
Tipo del documento:
Article