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The Year of the Rat: The Rat Genome Database at 20: a multi-species knowledgebase and analysis platform.
Smith, Jennifer R; Hayman, G Thomas; Wang, Shur-Jen; Laulederkind, Stanley J F; Hoffman, Matthew J; Kaldunski, Mary L; Tutaj, Monika; Thota, Jyothi; Nalabolu, Harika S; Ellanki, Santoshi L R; Tutaj, Marek A; De Pons, Jeffrey L; Kwitek, Anne E; Dwinell, Melinda R; Shimoyama, Mary E.
Afiliación
  • Smith JR; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Hayman GT; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Wang SJ; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Laulederkind SJF; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Hoffman MJ; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Kaldunski ML; Genomic Sciences and Precision Medicine Center and Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Tutaj M; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Thota J; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Nalabolu HS; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Ellanki SLR; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Tutaj MA; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • De Pons JL; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Kwitek AE; Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Dwinell MR; Genomic Sciences and Precision Medicine Center and Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Shimoyama ME; Genomic Sciences and Precision Medicine Center and Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Nucleic Acids Res ; 48(D1): D731-D742, 2020 01 08.
Article en En | MEDLINE | ID: mdl-31713623
ABSTRACT
Formed in late 1999, the Rat Genome Database (RGD, https//rgd.mcw.edu) will be 20 in 2020, the Year of the Rat. Because the laboratory rat, Rattus norvegicus, has been used as a model for complex human diseases such as cardiovascular disease, diabetes, cancer, neurological disorders and arthritis, among others, for >150 years, RGD has always been disease-focused and committed to providing data and tools for researchers doing comparative genomics and translational studies. At its inception, before the sequencing of the rat genome, RGD started with only a few data types localized on genetic and radiation hybrid (RH) maps and offered only a few tools for querying and consolidating that data. Since that time, RGD has expanded to include a wealth of structured and standardized genetic, genomic, phenotypic, and disease-related data for eight species, and a suite of innovative tools for querying, analyzing and visualizing this data. This article provides an overview of recent substantial additions and improvements to RGD's data and tools that can assist researchers in finding and utilizing the data they need, whether their goal is to develop new precision models of disease or to more fully explore emerging details within a system or across multiple systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratas / Mapeo Cromosómico / Genoma / Biología Computacional / Bases de Datos Genéticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratas / Mapeo Cromosómico / Genoma / Biología Computacional / Bases de Datos Genéticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos