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The First Racemic Total Syntheses of the Antiplasmodials Watsonianones A and B and Corymbone B.
Zhang, Xiao; Wu, Guiyun; Huo, Luqiong; Guo, Xueying; Qiu, Shengxiang; Liu, Hongxin; Tan, Haibo; Hu, Yingjie.
Afiliación
  • Zhang X; Institute of Tropical Medicine , Guangzhou University of Chinese Medicine , Guangzhou 510405 , People's Republic of China.
  • Wu G; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650 , People's Republic of China.
  • Huo L; Institute of Tropical Medicine , Guangzhou University of Chinese Medicine , Guangzhou 510405 , People's Republic of China.
  • Guo X; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650 , People's Republic of China.
  • Qiu S; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650 , People's Republic of China.
  • Liu H; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650 , People's Republic of China.
  • Tan H; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650 , People's Republic of China.
  • Hu Y; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , People's Republic of China.
J Nat Prod ; 83(1): 3-7, 2020 01 24.
Article en En | MEDLINE | ID: mdl-31721580
ABSTRACT
The first biomimetic total syntheses of three biologically meaningful acylphloroglucinols, watsonianones A and B and corymbone B, with potent antiplasmodial activity, were performed. Their total syntheses were carried out through a diversity-oriented synthetic strategy from congener 2,2,4,4-tetramethyl-6-(3-methylbutylidene)cyclohexane-1,3,5-trione with high step efficiency. The spontaneous enolization/air oxidation of the precursor 2,2,4,4-tetramethyl-6-(3-methylbutylidene)cyclohexane-1,3,5-trione through a singlet O2-induced Diels-Alder reaction pathway to assemble the key biosynthetic peroxide intermediate is also discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_malaria / 3_neglected_diseases Asunto principal: Floroglucinol / Ciclohexanonas / Furanos / Antimaláricos Idioma: En Revista: J Nat Prod Año: 2020 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_malaria / 3_neglected_diseases Asunto principal: Floroglucinol / Ciclohexanonas / Furanos / Antimaláricos Idioma: En Revista: J Nat Prod Año: 2020 Tipo del documento: Article