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An indentation-based approach to determine the elastic constants of soft anisotropic tissues.
Moghaddam, Amir Ostadi; Wei, Jie; Kim, Jiho; Dunn, Alison C; Wagoner Johnson, Amy J.
Afiliación
  • Moghaddam AO; Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 W Green Street, Urbana, IL, 61801, USA.
  • Wei J; Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 W Green Street, Urbana, IL, 61801, USA.
  • Kim J; Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 W Green Street, Urbana, IL, 61801, USA.
  • Dunn AC; Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 W Green Street, Urbana, IL, 61801, USA.
  • Wagoner Johnson AJ; Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 W Green Street, Urbana, IL, 61801, USA; Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, 320 Illini Union Bookstore, 807 S Wright St., Champaign, IL, 61820, USA; Carl R.
J Mech Behav Biomed Mater ; 103: 103539, 2020 03.
Article en En | MEDLINE | ID: mdl-31783285
Characterization of the mechanical properties of tissue can help to understand tissue mechanobiology, including disease diagnosis and progression. Indentation is increasingly used to measure the local mechanical properties of tissue, but it has not been fully adapted to capture anisotropic properties. This paper presents an indentation-based method to measure elastic constants of soft anisotropic tissues without additional mechanical tests. The approach uses measurement of the indentation modulus and the aspect ratio of the elliptical contact introduced by anisotropic mechanical properties of tissue to determine the elastic constants from finite element analysis. The imprinted area imparted by a fluorescent bead-coated spherical indenter showed the aspect ratio of the contact area, giving a generalized sense of the level of anisotropy, and instrumented indentation determined the indentation modulus. A parametric study using finite element simulation of the indentation tests established the relationship between the aspect ratio of contact and the non-dimensional ratios, Ex/Ey and Gxy/Ey; here, Ex and Ey are the Young's moduli (Ex > Ey) and Gxy is the shear modulus in the xy plane. For strongly anisotropic materials (Ex/Ey > 150), aspect ratio and indentation modulus are sufficient to determine Gxy and Ey. For weakly anisotropic materials, indentation modulus in the transverse direction, Ey, and the aspect ratio of contact in the anisotropic plane can be used to determine the elastic constants. The proposed approach improves the elastic characterization of soft, anisotropic biological materials from indentation and helps to elucidate the complex mechanical behavior of soft anisotropic tissues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anisotropía Idioma: En Revista: J Mech Behav Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anisotropía Idioma: En Revista: J Mech Behav Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
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