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In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.
Mandt, Rebecca E K; Lafuente-Monasterio, Maria Jose; Sakata-Kato, Tomoyo; Luth, Madeline R; Segura, Delfina; Pablos-Tanarro, Alba; Viera, Sara; Magan, Noemi; Ottilie, Sabine; Winzeler, Elizabeth A; Lukens, Amanda K; Gamo, Francisco Javier; Wirth, Dyann F.
Afiliación
  • Mandt REK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain.
  • Sakata-Kato T; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Luth MR; Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
  • Segura D; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain.
  • Pablos-Tanarro A; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain.
  • Viera S; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain.
  • Magan N; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain.
  • Ottilie S; Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
  • Winzeler EA; Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
  • Lukens AK; Skaggs School of Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
  • Gamo FJ; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Wirth DF; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA.
Sci Transl Med ; 11(521)2019 12 04.
Article en En | MEDLINE | ID: mdl-31801884
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_malaria / 3_zoonosis Asunto principal: Parásitos / Malaria Falciparum / Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH / Inhibidores Enzimáticos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_malaria / 3_zoonosis Asunto principal: Parásitos / Malaria Falciparum / Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH / Inhibidores Enzimáticos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos