Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia.
Medicine (Baltimore)
; 98(49): e18240, 2019 Dec.
Article
en En
| MEDLINE
| ID: mdl-31804351
ABSTRACT
BACKGROUND:
FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377Gâ>âA (rs2234767) and FAS-670Aâ>âG (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian population while the outcomes are inconsistent. To derive a more precise assessment of the association between breast cancer susceptibility with FAS gene promoter SNPs, a meta-analysis of published studies was performed. MATERIAL ANDMETHODS:
We systematically searched PubMed, Embase, Web of Science, and the Chinese biomedical database (CBM) for papers published until November 1, 2018. Odds ratio (OR) with 95% confidential interval (95%CI) was conducted to evaluate the associations. Statistical analysis was conducted using Stata13.0 software. A total of 8 studies covering 2564 cases and 2633 controls were included.RESULTS:
The integrated results suggest the following For the FAS-1377G/A polymorphism, we only found significant associations for allele G vs allele A (ORâ=â1.100, 95%CIâ=â1.004-1.206, Pâ=â.040). After stratification by ethnicity, a significant association was observed only for the AA+GA vs GG genotype in East Asian populations (ORâ=â1.177, 95% CIâ=â1.010-1.371, Pâ=â.037). The association was not found in West Asian populations. For the FAS -670A/G polymorphism, no association with cancer risk was found in any comparison model. Sensitivity analysis suggests that the meta-analysis results obtained after excluding any single study were similar to the original ones, suggesting that the meta-analysis results were not significantly affected by any single study.CONCLUSION:
These results indicated that FAS-1377G/A polymorphism may contribute to the increased breast cancer susceptibility and could be a promising target for cancer risk prediction. Further studies are needed to determine if the FAS gene confers a risk of breast cancer in other ethnic groups, such as Africans and Latin Americans.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_breast_cancer
Asunto principal:
Neoplasias de la Mama
/
Receptor fas
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Límite:
Female
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2019
Tipo del documento:
Article