Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology.
Bioorg Med Chem
; 28(1): 115213, 2020 01 01.
Article
en En
| MEDLINE
| ID: mdl-31810890
Palabras clave
CFU, colony-forming units; HPLC, high-peformance liquid chromatography; LDA, lithium diisopropylamide; LORA, low oxygen recovery assay; LiTMP, lithium tetramethylpiperidide; M.tb, Mycobacterium tuberculosis; MABA, microplate alamar blue assay; MIC(90), minimum concentration for 90% inhibition; TB, tuberculosis; hERG, the alpha subunit of a K+ channel that contributes to the electrical activity of the heart
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_tuberculosis
Asunto principal:
Diarilquinolinas
/
Mycobacterium tuberculosis
/
Antituberculosos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda