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Validation of a neuroendocrine-like classifier confirms poor outcomes in patients with bladder cancer treated with cisplatin-based neoadjuvant chemotherapy.
Grivas, Petros; Bismar, Tarek A; Alva, Aijai S; Huang, Huei-Chung; Liu, Yang; Seiler, Roland; Alimohamed, Nimira; Cheng, Liang; Hyndman, M Eric; Dabbas, Bashar; Black, Peter C; Davicioni, Elai; Wright, Jonathan L; Ornstein, Moshe C; Mian, Omar Y; Kaimakliotis, Hristos Z; Gibb, Ewan A; Lotan, Yair.
Afiliación
  • Grivas P; Division of Oncology, Department of Medicine, University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA.
  • Bismar TA; Department of Pathology and Laboratory Medicine, University of Calgary, Cumming School of Medicine, Calgary, AB, Canada.
  • Alva AS; Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
  • Huang HC; Decipher Biosciences, Inc., Vancouver, Canada.
  • Liu Y; Decipher Biosciences, Inc., Vancouver, Canada.
  • Seiler R; Department of Urology, University of Bern, Bern, Switzerland.
  • Alimohamed N; Department of Medical Oncology, Tom Baker Cancer Center, University of Calgary, Calgary, AB, Canada.
  • Cheng L; Department of Pathology, Indiana University, Indianapolis, IN.
  • Hyndman ME; Department of Urology, University of Calgary, Cumming School of Medicine, Calgary, AB, Canada.
  • Dabbas B; Decipher Biosciences, Inc., Vancouver, Canada.
  • Black PC; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Davicioni E; Decipher Biosciences, Inc., Vancouver, Canada.
  • Wright JL; Department of Urology, University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA.
  • Ornstein MC; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH.
  • Mian OY; Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH.
  • Kaimakliotis HZ; Department of Urology, Indiana University, Indianapolis, IN.
  • Gibb EA; Decipher Biosciences, Inc., Vancouver, Canada.
  • Lotan Y; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: yair.lotan@utsouthwestern.edu.
Urol Oncol ; 38(4): 262-268, 2020 04.
Article en En | MEDLINE | ID: mdl-31812633
ABSTRACT

PURPOSE:

Neuroendocrine (NE)-like carcinoma is a newly recognized molecular subtype of conventional urothelial carcinoma of the bladder with transcriptomic profiles and clinical outcomes highly similar to histological NE carcinoma. The identification of NE-like tumors is challenging, as these tumors often appear histologically like urothelial carcinoma and can be missed by routine morphological criteria. We previously developed a single-sample classifier to identify NE-like tumors, which we aimed to validate in an independent cohort. MATERIALS AND

METHODS:

A single-sample genomic classifier was performed on transurethral specimens from a retrospective multicenter cohort of 234 patients who underwent cisplatin-based neoadjuvant chemotherapy and subsequent radical cystectomy. Outcomes were compared for NE-like vs. non-NE-like.

RESULTS:

We identified 10 patients with urothelial tumors of the NE-like subtype, all of which had robust gene expression of neuronal markers, but did not express markers associated with basal or luminal tumors. The cancer-specific mortality rates were significantly higher compared to non-NE-like tumors (P < 0.001), with 5 of the 10 patients dying within 12 months from surgery.

CONCLUSIONS:

The single-sample classifier was able to identify urothelial carcinomas with NE-like subtype. These NE-like tumors have demonstrated transcriptomic profiles and clinical behavior similar to histological NE tumors across multiple patient cohorts. We propose that NE-like tumors should be managed similarly to histological NE tumors, and that standard treatments for small cell lung cancer as well as novel strategies may be evaluated in these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Cisplatino / Terapia Neoadyuvante / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Urol Oncol Asunto de la revista: NEOPLASIAS / UROLOGIA Año: 2020 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Cisplatino / Terapia Neoadyuvante / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Urol Oncol Asunto de la revista: NEOPLASIAS / UROLOGIA Año: 2020 Tipo del documento: Article
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