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The Role of Deubiquitinases in Vascular Diseases.
Wang, Biqing; Cai, Wenbin; Ai, Ding; Zhang, Xu; Yao, Liu.
Afiliación
  • Wang B; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China.
  • Cai W; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China.
  • Ai D; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China.
  • Zhang X; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China. xuzhang@tmu.edu.cn.
  • Yao L; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China. yaoliu@tmu.edu.cn.
J Cardiovasc Transl Res ; 13(2): 131-141, 2020 04.
Article en En | MEDLINE | ID: mdl-31823221
Deubiquitinases (DUBs) are a major component of the ubiquitin-proteasome system in eukaryotic cells; the system plays a crucial role in many biological processes, such as inflammation, oxidative stress, and cell apoptosis, which are important in vascular biology and pathology. DUBs have drawn significant attention in recent years, and their function is increasingly linked with vascular diseases. In this review, we summarize the indirect and direct evidence for the effects of DUBs on atherosclerosis, abdominal aortic aneurysm, angiogenesis, and hypertension, and point out pathways that could be pursued for investigating DUBs. Intervention in the function of DUBs in vascular diseases has potential therapeutic value.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Vasculares / Vasos Sanguíneos / Enzimas Desubicuitinizantes Límite: Animals / Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Vasculares / Vasos Sanguíneos / Enzimas Desubicuitinizantes Límite: Animals / Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China
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