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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions.
Li, Xia; Frechen, Sebastian; Moj, Daniel; Lehr, Thorsten; Taubert, Max; Hsin, Chih-Hsuan; Mikus, Gerd; Neuvonen, Pertti J; Olkkola, Klaus T; Saari, Teijo I; Fuhr, Uwe.
Afiliación
  • Li X; Department I of Pharmacology, Center for Pharmacology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Gleueler Straße 24, 50931, Cologne, Germany.
  • Frechen S; Clinical Pharmacometrics, Bayer AG, Leverkusen, Germany.
  • Moj D; Department of Pharmacy, Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
  • Lehr T; Department of Pharmacy, Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
  • Taubert M; Department I of Pharmacology, Center for Pharmacology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Gleueler Straße 24, 50931, Cologne, Germany.
  • Hsin CH; Department I of Pharmacology, Center for Pharmacology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Gleueler Straße 24, 50931, Cologne, Germany.
  • Mikus G; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.
  • Neuvonen PJ; Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Olkkola KT; Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Saari TI; Department of Anaesthesiology and Intensive Care, University of Turku and Turku University Hospital Turku, Turku, Finland.
  • Fuhr U; Department I of Pharmacology, Center for Pharmacology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Gleueler Straße 24, 50931, Cologne, Germany. uwe.fuhr@uk-koeln.de.
Clin Pharmacokinet ; 59(6): 781-808, 2020 06.
Article en En | MEDLINE | ID: mdl-31853755
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interacciones Farmacológicas / Citocromo P-450 CYP3A / Voriconazol / Citocromo P-450 CYP2C19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Pharmacokinet Año: 2020 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interacciones Farmacológicas / Citocromo P-450 CYP3A / Voriconazol / Citocromo P-450 CYP2C19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Pharmacokinet Año: 2020 Tipo del documento: Article País de afiliación: Alemania