Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss.
Cell Metab
; 31(2): 233-249.e4, 2020 02 04.
Article
en En
| MEDLINE
| ID: mdl-31866441
ABSTRACT
The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetes is currently unclear. Here, we determined the contributions of hepatic VLDL1-triglyceride production rate and VLDL1-palmitic acid content to changes in intra-pancreatic fat and return of first phase insulin response in a subgroup of the Diabetes Remission Clinical Trial. Liver fat, VLDL1-triglyceride production, and intra-pancreatic fat decreased after weight loss and remained normalized after 24 months of remission. First-phase insulin response remained increased only in those maintaining diabetes remission. Compared with those in remission at 24 months, individuals who relapsed after initial remission had a greater rise in the content of VLDL1-triglyceride and VLDL1-palmitic acid, re-accumulated intra-pancreatic fat, and lost first-phase response by 24 months. Thus, we observed temporal relationships between VLDL1-triglyceride production, hepatic palmitic acid flux, intra-pancreatic fat, and ß-cell function. Weight-related disordered fat metabolism appears to drive development and reversal of type 2 diabetes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triglicéridos
/
Pérdida de Peso
/
Ácido Palmítico
/
Diabetes Mellitus Tipo 2
/
Células Secretoras de Insulina
/
Lipoproteínas VLDL
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cell Metab
Asunto de la revista:
METABOLISMO
Año:
2020
Tipo del documento:
Article