Current and emerging therapeutic options for the management of functional dyspepsia.
Expert Opin Pharmacother
; 21(3): 365-376, 2020 Feb.
Article
en En
| MEDLINE
| ID: mdl-31899982
ABSTRACT
Introduction:
Functional Dyspepsia (FD), defined as chronic symptoms originating from the gastroduodenal region in absence of readily identifiable organic disease, is one of the most common gastrointestinal disorders. FD is divided into two subgroups Post-Prandial Distress Syndrome (PDS) or meal-related FD, characterized by postprandial fullness and early satiation, and Epigastric Pain Syndrome (EPS) or meal-unrelated FD, characterized by epigastric pain and burning.Areas covered This review summarizes the existing and off-label therapeutic options for FD.Expert opinion The identification of mechanisms, the Rome IV classification, the reduction of PDS/EPS overlap and pictograms for symptom identification allow a better diagnosis and a more targeted treatment choice. Acotiamide, a first-in-class prokinetic agent available only in Japan and India, is the only agent of proven efficacy for FD, but clinicians use acid-suppressive therapy, prokinetics, neuromodulators and herbal therapies for treating FD symptoms. New emerging targets are duodenal low-grade inflammation with eosinophils and duodenal or other modified luminal microbiota.Palabras clave
Functional dyspepsia; acid suppressants; anti-inflammatory approach; duodenal inflammation; duodenal microbiota; epigastric pain syndrome; functional dyspepsia overlap; herbal medicines; histamine receptor blockers; medicinal herbal preparations; neuromodulators; overlap; post prandial distress syndrome; postprandial distress syndrome; potassium-competitive acid blockers; probiotics; prokinetics; proton pomp inhibitors; therapeutic gap
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiazoles
/
Benzamidas
/
Dispepsia
Límite:
Humans
Idioma:
En
Revista:
Expert Opin Pharmacother
Asunto de la revista:
FARMACOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Bélgica