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Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration.
Casaletto, K B; Staffaroni, A M; Wolf, A; Appleby, B; Brushaber, D; Coppola, G; Dickerson, B; Domoto-Reilly, K; Elahi, F M; Fields, J; Fong, J C; Forsberg, L; Ghoshal, N; Graff-Radford, N; Grossman, M; Heuer, H W; Hsiung, G-Y; Huey, E D; Irwin, D; Kantarci, K; Kaufer, D; Kerwin, D; Knopman, D; Kornak, J; Kramer, J H; Litvan, I; Mackenzie, I R; Mendez, M; Miller, B; Rademakers, R; Ramos, E M; Rascovsky, K; Roberson, E D; Syrjanen, J A; Tartaglia, M C; Weintraub, S; Boeve, B; Boxer, A L; Rosen, H; Yaffe, K.
Afiliación
  • Casaletto KB; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Staffaroni AM; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Wolf A; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Appleby B; Case Western Reserve University, Cleveland, Ohio, USA.
  • Brushaber D; Mayo Clinic, Rochester, Minnesota, USA.
  • Coppola G; University of California, Los Angeles, California, USA.
  • Dickerson B; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Domoto-Reilly K; University of Washington, Seattle, Washington, USA.
  • Elahi FM; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Fields J; Mayo Clinic, Rochester, Minnesota, USA.
  • Fong JC; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Forsberg L; Case Western Reserve University, Cleveland, Ohio, USA.
  • Ghoshal N; Washington University, St. Louis, Illinois, USA.
  • Graff-Radford N; Mayo Clinic, Rochester, Minnesota, USA.
  • Grossman M; University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Heuer HW; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Hsiung GY; University of British Columbia, Vancouver, British Columbia, Canada.
  • Huey ED; Columbia University, New York, New York, USA.
  • Irwin D; University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Kantarci K; Mayo Clinic, Rochester, Minnesota, USA.
  • Kaufer D; University of North Carolina, Chapel Hill, North Carolina, USA.
  • Kerwin D; University of Texas Southwestern, Dallas, Texas, USA.
  • Knopman D; Mayo Clinic, Rochester, Minnesota, USA.
  • Kornak J; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Kramer JH; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Litvan I; Parkinson and Other Movement Disorder Center, Department of Neuroscience, University of California, San Diego, San Diego, California, USA.
  • Mackenzie IR; University of British Columbia, Vancouver, British Columbia, Canada.
  • Mendez M; University of California, Los Angeles, California, USA.
  • Miller B; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Rademakers R; Mayo Clinic, Jacksonville, Florida, USA.
  • Ramos EM; University of California, Los Angeles, USA.
  • Rascovsky K; University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Roberson ED; University of Alabama, Birmingham, Alabama, USA.
  • Syrjanen JA; Mayo Clinic, Rochester, Minnesota, USA.
  • Tartaglia MC; University of Toronto, Toronto, Ontario, Canada.
  • Weintraub S; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, Illinois, USA.
  • Boeve B; Mayo Clinic, Rochester, Minnesota, USA.
  • Boxer AL; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Rosen H; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
  • Yaffe K; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Alzheimers Dement ; 16(1): 91-105, 2020 01.
Article en En | MEDLINE | ID: mdl-31914227
INTRODUCTION: Leisure activities impact brain aging and may be prevention targets. We characterized how physical and cognitive activities relate to brain health for the first time in autosomal dominant frontotemporal lobar degeneration (FTLD). METHODS: A total of 105 mutation carriers (C9orf72/MAPT/GRN) and 69 non-carriers reported current physical and cognitive activities at baseline, and completed longitudinal neurobehavioral assessments and brain magnetic resonance imaging (MRI) scans. RESULTS: Greater physical and cognitive activities were each associated with an estimated >55% slower clinical decline per year among dominant gene carriers. There was also an interaction between leisure activities and frontotemporal atrophy on cognition in mutation carriers. High-activity carriers with frontotemporal atrophy (-1 standard deviation/year) demonstrated >two-fold better cognitive performances per year compared to their less active peers with comparable atrophy rates. DISCUSSION: Active lifestyles were associated with less functional decline and moderated brain-to-behavior relationships longitudinally. More active carriers "outperformed" brain volume, commensurate with a cognitive reserve hypothesis. Lifestyle may confer clinical resilience, even in autosomal dominant FTLD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Cognición / Degeneración Lobar Frontotemporal / Actividades Recreativas / Pruebas Neuropsicológicas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Cognición / Degeneración Lobar Frontotemporal / Actividades Recreativas / Pruebas Neuropsicológicas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos