Long-Term Outcomes of Biodegradable Versus Second-Generation Durable Polymer Drug-Eluting Stent Implantations for Myocardial Infarction.
JACC Cardiovasc Interv
; 13(1): 97-111, 2020 01 13.
Article
en En
| MEDLINE
| ID: mdl-31918948
ABSTRACT
OBJECTIVES:
This study sought to compare outcomes between biodegradable polymer drug-eluting stent (BP-DES) and second-generation durable polymer drug-eluting stent (DP-DES) implantations for acute myocardial infarction (MI) using a nationwide dataset.BACKGROUND:
Data regarding outcomes of BP-DES versus second-generation DP-DES are inconclusive.METHODS:
Among 13,104 patients with acute MI in a nationwide registry who underwent percutaneous coronary intervention (November 2011 to December 2015), BP-DES and second-generation DP-DES were implanted in 2,261 (21.7%) and 8,182 patients (78.3%), respectively. Major adverse cardiac events (MACE) (all-cause death, recurrent MI, or any revascularization) were compared in multivariable Cox regression, propensity score (PS) matched, and underwent PS-adjusted analyses.RESULTS:
MACE occurred in 1,492 (14.3%) patients during a median 723-day follow-up. MACE were less frequent with BP-DES implantation than with second-generation DP-DES implantation (entire cohort hazard ratio [HR] 0.845; 95% confidence interval [CI] 0.740 to 0.965; PS-matched HR 0.669; 95% CI 0.550 to 0.814). Risk of all-cause death (entire cohort HR 0.831; 95% CI 0.692 to 0.997; PS-matched HR 0.752; 95% CI 0.495 to 0.931), cardiac death (entire cohort HR 0.685; 95% CI 0.542 to 0.865; PS-matched HR 0.613; 95% CI 0.463 to 0.872), recurrent MI (entire cohort HR 0.662; 95% CI 0.466 to 0.941; PS-matched HR 0.611; 95% CI 0.427 to 0.898), and heart failure readmission (entire cohort HR 0.625; 95% CI 0.447 to 0.875; PS-matched HR 0.584; 95% CI 0.385 to 0.887) was less with BP-DES implantation. There were no significant group differences in the incidences of any revascularization, stroke, and definite or probable stent thrombosis.CONCLUSIONS:
In patients with acute MI who underwent percutaneous coronary intervention, BP-DES implantation is associated with improved outcomes compared with second-generation DP-DES implantation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polímeros
/
Implantes Absorbibles
/
Stents Liberadores de Fármacos
/
Intervención Coronaria Percutánea
/
Infarto del Miocardio
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
JACC Cardiovasc Interv
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Corea del Sur