Your browser doesn't support javascript.
loading
The angiotensin II receptor-neprilysin inhibitor LCZ696 attenuates the progression of proteinuria in type 2 diabetic rats.
Rahman, Asadur; Sherajee, Shamshad J; Rafiq, Kazi; Kobara, Hideki; Masaki, Tsutomu; Nakano, Daisuke; Morikawa, Takashi; Konishi, Yoshio; Imanishi, Masahito; Nishiyama, Akira.
Afiliación
  • Rahman A; Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Sherajee SJ; Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Rafiq K; Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Kobara H; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Masaki T; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Nakano D; Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Morikawa T; Division of Hypertension and Nephrology, Osaka General Hospital, Osaka, Japan.
  • Konishi Y; Division of Hypertension and Nephrology, Osaka General Hospital, Osaka, Japan.
  • Imanishi M; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Nishiyama A; Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan. Electronic address: akira@med.kagawa-u.ac.jp.
J Pharmacol Sci ; 142(3): 124-126, 2020 Mar.
Article en En | MEDLINE | ID: mdl-31924408
ABSTRACT
We examined the effects of the angiotensin receptor-neprilysin inhibitor LCZ696 on overt proteinuria and renal injury in type 2 diabetic Otsuka-Long- Evans-Tokushima-Fatty (OLETF) rats. Aged OLETF rats were also treated with either valsartan or valsartan plus hydralazine for comparison. LCZ696 caused greater attenuation of the progression of proteinuria than either valsartan alone or valsartan combined with hydralazine. Reduced glomerular injury and tubulointerstitial fibrosis were also observed in LCZ696-treated rats. Moreover, LCZ696 prevented increases in blood urea nitrogen (BUN) and creatinine levels. These data suggest that LCZ696 elicits a reno-protective effect against type 2 diabetes with overt proteinuria.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteinuria / Tetrazoles / Diabetes Mellitus Tipo 2 / Antagonistas de Receptores de Angiotensina / Aminobutiratos Límite: Animals Idioma: En Revista: J Pharmacol Sci Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteinuria / Tetrazoles / Diabetes Mellitus Tipo 2 / Antagonistas de Receptores de Angiotensina / Aminobutiratos Límite: Animals Idioma: En Revista: J Pharmacol Sci Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón