The aqueous extract of Gentianella acuta improves isoproterenol­induced myocardial fibrosis via inhibition of the TGF­ß1/Smads signaling pathway.

Yang, Hong-Xia; Xu, Geng-Rui; Zhang, Chuang; Sun, Jia-Huan; Zhang, Yue; Song, Jun-Na; Li, Yun-Feng; Liu, Yu; Li, Ai-Ying

The aqueous extract of Gentianella acuta improves isoproterenolinduced myocardial fibrosis via inhibition of the TGFß1/Smads signaling pathway.

Yang, Hong-Xia; Xu, Geng-Rui; Zhang, Chuang; Sun, Jia-Huan; Zhang, Yue; Song, Jun-Na; Li, Yun-Feng; Liu, Yu; Li, Ai-Ying.

Afiliación

Yang HX; Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Xu GR; Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Zhang C; Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Sun JH; Department of Medical Laboratory Science, College of Integration of Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Zhang Y; Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Song JN; Department of Medicinal Plant, College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Li YF; Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Liu Y; Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.
Li AY; Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.

Int J Mol Med ; 45(1): 223-233, 2020 01.

Article en En | MEDLINE | ID: mdl-31939619

Asunto(s)

Gentianella/química; Miocardio/patología; Extractos Vegetales/farmacología; Transducción de Señal; Proteínas Smad/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo; Agua/química; Actinas/metabolismo; Animales; Colágeno/metabolismo; Fibrosis; Isoproterenol; Masculino; Modelos Biológicos; Fosforilación/efectos de los fármacos; Ratas Sprague-Dawley; Receptores de Factores de Crecimiento Transformadores beta/metabolismo; Remodelación Ventricular/efectos de los fármacos

Palabras clave

Gentianella acuta; isoproterenol; myocardial fibrosis; transforming growth factor-ß1; transforming growth factor-ß1/mothers against decapentaplegic homolog signaling pathway

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agua / Extractos Vegetales / Transducción de Señal / Gentianella / Proteínas Smad / Factor de Crecimiento Transformador beta1 / Miocardio Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Med Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2020 Tipo del documento: Article

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